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KMID : 0374920040250010077
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Inje Medical Journal
2004 Volume.25 No. 1 p.77 ~ p.85
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Linkage between monoamine oxidase A promoter polymorphism and male panic patients
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Choi Young-Hee
Woo Jong-Min
Park Hun-Ku
Cho Woo-Yeon
Yoon Haye-Young
Yoon Kyung-Sik
Cho Dae-Yeon
Hong Kyung-Sue
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Abstract
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Objectives: Genetic variation of the monoamine oxidase (MAO) A promoter gene polymorphism has been associated with its functional capacity. The authors tried to find the association between MAO A promoter polymorphism and panic disorder.
Methods: 317 patients with panic disorder and 92 normal controls were enrolled in this study. 308 patients and 84 normal controls were completed study.
Results: There was significant difference in allele frequencies of MAO A promoter polymorphism between male panic patients and normal controls (s allele: 60.7% vs. 44.3%, 1 allele: 39.3% vs 55.7%, x^(2)=10.008, df=1, p=0.002). The frequencies of MAO A promoter alleles between panic disorder and normal controls were 2 repeat (1.1% vs. 1.2%), 3 repeat (58.3% vs. 45.8%), 4 repeat (40.6% vs. 53.0%)(x2=8.368, df=2, p=0.015).
Conclusion: Our results suggest that MAO A promoter gene may be related to panic disorder.
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KEYWORD
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Monoamine oxidase, Treatment response, Promoter, Panic disorder, Gene, Polymorphism
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